Acdsee free12/20/2023 In response to inflammatory cytokines, increasingly IL-6, the liver produces increased amounts of hepcidin. The presence of both anemia of chronic disease and dietary iron deficiency results in a more severe anemia.Īnemia is defined by hemoglobin (Hb) concentration It is usually normocytic, but can be microcytic. Classification Īnemia of chronic disease is usually mild but can be severe. It is also known as anemia of inflammation, or anemia of inflammatory response. Other mechanisms may also play a role, such as reduced erythropoiesis. As a consequence, circulating iron levels are reduced. Hepcidin production and release shuts down ferroportin, a protein that controls export of iron from the gut and from iron storing cells (e.g. These conditions all produce elevation of interleukin-6, which stimulates hepcidin production and release from the liver. Medical condition Anemia of chronic diseaseĪnemia of chronic disease ( ACD) or anemia of chronic inflammation is a form of anemia seen in chronic infection, chronic immune activation, and malignancy.
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